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U.S. EPA Toxicity Category Table

EPA Toxicity Categories

Toxicity Categories Signal Word Requirement
Category I
Category II
Category III
Category IV
DANGER
WARNING
CAUTION
NONE Required

The U.S. Environmental Protection Agency assigns toxicity categories based on a substance's potency (ability to cause harm at low doses) by various routes of exposure (e.g., oral, inhalation, dermal). Precautionary labels are required to bear a Signal Word ("Danger" and/or "Poison"; "Warning"; or "Caution") corresponding to one of four categories of toxicity. Additionally, the statement, "Keep out of reach of children" is required on the label. The Signal Word must appear with sufficient prominence relative to other front panel text and graphic material to assure that it will not be overlooked under customary conditions of purchase and use.
Table 1 - Toxicity Categories
Study
Category I
Category II
Category III
Category IV
Acute Oral Up to and including 50 mg/kg > 50 thru 500 mg/kg > 500 thru 5000 mg/kg > 5000 mg/kg
Acute Dermal Up to and including 200 mg/kg > 200 thru 2000 mg/kg > 2000 thru 5000 mg/kg > 5000 mg/kg
Acute Inhalation1 Up to and including 0.05 mg/liter > 0.05 thru 0.5 mg/liter > 0.5 thru 2 mg/liter > 2 mg/liter
Primary
Eye Irritation
Corrosive (irreversible destruction of ocular tissue) or corneal involvement or irritation persisting for more than 21 days Corneal involvement or other eye irritation clearing in 8-21 days Corneal involvement or other eye irritation clearing in 7 days or less Minimal effects clearing in less than 24 hours
Primary
Skin Irritation
Corrosive (tissue destruction into the dermis and/or scarring) Severe irritation at 72 hours (severe erythema or edema) Moderate irritation at 72 hours (moderate erythema) Mild or slight irritation at 72 hours (no irritation or slight erythema)
1 4 hr exposure


 

 




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